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Adenosine in the nervous system

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Published by Academic Press in London, San Diego .
Written in English

Subjects:

  • Adenine Nucleotides -- physiology.,
  • Adenosine -- physiology.,
  • Nervous System -- physiology.,
  • Receptors, Purinergic -- physiology.,
  • Adenosine -- Metabolism.,
  • Adenosine -- Pharmacokinetics.,
  • Nervous system -- Metabolism.,
  • Purines -- Receptors.,
  • Adenosine triphosphate.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by T.W. Stone.
SeriesNeuroscience perspectives
ContributionsStone, T. W.
The Physical Object
Paginationxvii, 278 p. ;
Number of Pages278
ID Numbers
Open LibraryOL18010748M
ISBN 10012672640X
LC Control Number92004958

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Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacology and clinical therapeutic potential of adenosine and its analogues in the nervous system. Among the topics covered are adenosine transport in nervous systemtissues, adenosine production and metabolism and the electropharmacology of adenosine. Get this from a library! Adenosine in the nervous system. [T W Stone;] -- This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology, pharmacology and clinical therapeutic potential of adenosine and its. Adenosine in the nervous system. London ; San Diego: Academic Press, © (OCoLC) Online version: Adenosine in the nervous system. London ; San Diego: Academic Press, © (OCoLC) Document Type: Book: All Authors / Contributors: T W Stone.

Adenosine in the Nervous System This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacology and clinical therapeutic potential of adenosine and its analogues in the nervous system. Among the topics covered are adenosine transport in nervous systemtissues, adenosine production and metabolism and the.   The omnipresence of adenosine and A 2A and A 1 ARs in all nervous system cells (neurons and glia), together with the intensive release of adenosine following insults, makes adenosine a kind of “maestro” of the tripartite synapse in the homeostatic coordination of the brain by: Adenosine is involved in a diverse array of functions in the central nervous system. Although in a general sense many of its effects are inhibitory, consistent with its proposed roles as an endogenous anticonvulsant, neuroprotectant, and sleep-inducing factor, this differs depending on the brain system and the complement of adenosine receptors. Adenosine is one of the principal neuromodulators in the brain and acts on four specific receptor subtypes: the A1, A2A, A2B and A3 receptors. Adenosine concentrations normally reached in the extracellular space are in the nanomolar range and may stimulate the high affinity A1 and A2A receptors.

Adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally present in the extracellular space in brain tissue leads to inhibitory effects that appear to be mediated by both adenosine Cited by: REVIEW Adenosine in the central nervous system: release mechanisms and extracellular concentrations Serena Latini and Felicita Pedata Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy Abstract Adenosine has several functions within the CNS that involve an inhibitory tone of neurotransmission and. This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacology and clinical therapeutic potential of adenosine and its analogues in the nervous system. Adenosine has physiological functions throughout the nervous system. In both the central (CNS) and peripheral nervous systems (PNS), adenosine is a neuromodulator, exerting a fine-tuned regulation of synaptic transmission. These actions are mediated by metabotropic adenosine receptors (A 1 and A 2A). In the PNS, the neuromuscular junction is an.